epsC [2017-07-26 15:18:21]

UDP-sugar epimerase, required for extracellular polysaccharide synthesis, this gene is inactive in B. subtilis 168

Locus: BSU34350

Isoelectric point: 8.77

Molecular weight: 66.09 kDa

Protein length: 598 aa

Gene length: 1794 bp

Function: biofilm formation

Product: unknown

Essential: no

Synonyms: yveM

Genomic Context

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Categories containing this gene/protein

• Lifestyles → Exponential and early post-exponential lifestyles → Biofilm formation
• Lifestyles → Exponential and early post-exponential lifestyles → Biofilm formation → Matrix polysaccharide synthesis
• Groups of genes → Membrane proteins

Gene

Coordinates: 3,526,407 → 3,528,203

The protein

Protein family

• polysaccharide synthase family (according to Swiss-Prot)

Paralogous protein(s)

• SpsM (YodU, YodU)

Localization

• cell membrane (according to Swiss-Prot)

Expression and Regulation

Operons

• Genes: epsA-epsB-epsC-epsD-epsE-epsF-epsG-epsH-epsI-epsJ-epsK-epsL-epsM-epsN-epsO
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • RemA: activation, PubMed, in RemA regulon
  • AbrB: repression, PubMed, in AbrB regulon
  • SinR: anti-activation, (prevents binding of RemA) PubMed, in SinR regulon
  • EAR riboswitch: processive antitermination, in EAR riboswitch

  Regulation

  • repressed by SinR PubMed

  Additional information

  • induction by sequestration of SinR by SinI or SlrA PubMed
  • expression is increased in rsiX mutants PubMed

Biological materials

Mutant

• MGNA-A071 (yveM::erm), available at the NBRP B. subtilis, Japan

Labs working on this gene/protein

• Richard Losick, Harvard Univ., Cambridge, USA homepage

References

Reviews

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The EAR RNA switch

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